There was no immediate confirmation of what caused the blast on Saturday afternoon, nor whether there were any casualties, but Afghan users on Twitter said alarms could be heard ringing in the area.
Paramedics carried the wounded away on stretchers in a street littered with broken glass and mangled cars, a witness interviewed by the Reuters news agency said.
The bomb was placed in a Toyota sedan, a security official at the scene said.
Parts of the car ripped apart by the force of the blast were scattered along the street.
Glass was blown out of the windows of the Shinozada hospital and a six-storey building opposite.
On its website, the Shinozada is described as Afghanistan's first private hospital.
There have been a number of attacks in the city within the past month.
The blast happened in front of Shenozada Clinic not A. Haq Sq. pic.twitter.com/LD5tHSWw3F
— Karim Haidari (@FkHaidari) August 22, 2015
At least four people were killed at Kabul airport on August 10 and dozens of civilians were killed in multiple suicide attacks a week earlier.At least 35 people were killed and hundreds more have been wounded in separate bomb attacks on Friday, August 7th 2015 in the Afghan capital Kabul.
A suicide bomber blew himself up near the city's police academy on Friday evening, killing about 20 recruits.
A short while later a large explosion was heard north of the airport.
In the early hours of Friday, a truck carrying explosives was detonated near an army base in the Shah Shahid area, claiming 15 lives.
Source: Bloom Gist, Agencies